CaMKII- Isoform Regulation of Neointima Formation After Vascular Injury
نویسندگان
چکیده
CaMKII 2 and decrease in CaMKII isoform content was observed in both medial smooth muscle and adventitial fibroblasts. Neointimal VSM cells expressed primarily the 2 isoform. Incubation of the injured vessel with adenovirus encoding siRNA targeting CaMKII isoforms prevented upregulation of the 2 isoform in the media and adventitia; inhibited cell proliferation assessed by PCNA expression in both layers and markedly inhibited neointima formation and
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تاریخ انتشار 2008